2024年4月23日发(作者：)

ABC transporter - 高中教育

ABC转运蛋白简介

ABC transporter1 What is the ABC transporter? 2 Function 3 Structure

4 Mechanism of transport 5 ABC importers 6 ABC exporters 7 Role in

multidrug resistance 8 Reversal of multidrug resistance 9 Physiological

role 10 Methods to characterize ABC transporter

ABC转运蛋白简介

1 What is the ABC transporter? Proteins are classified as ABC

transporters based on the sequence and organization of their

ATP-binding cassette (ABC) domain(s) . ATP-binding cassette

transporters ( ABC-transporter ) are transmembrane proteins that utilize

the energy of adenosine triphosphate (ATP) hydrolysis to carry out

certain biological processes including translocation of various substrates

across membranes and non-transport-related processes such as

translation of RNA and DNA repair. ABC transporters are involved in

tumour resistance, cystic fibrosis, bacterial multidrug resistance, and a

range of other inherited human diseases.

ABC转运蛋白简介

2 Function2.1 Prokaryotic ABC proteins 2.2 Eukaryotic ABC proteins

ABC转运蛋白简介

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ABC transporters utilize the energy of ATP hydrolysis to transport various

substrates across cellular membranes. They are divided into three main

functional categories. Importers(in prokaryotes) Exporters or

effluxers(in both prokaryotes and eukaryotes) The third subgroup do

not function as transporters,but are rather involved in translation of RNA

and DNA repair processes.

ABC转运蛋白简介

2.1 Prokaryotic ABC proteins Bacterial ABC importers are essential in

cell viability, virulence and pathogenicity. Other than functioning in

transport, some bacterial ABC proteins are also involved in the regulation

of several physiological processes. In bacterial efflux systems, certain

substances include surface components of the bacterial cell, proteins

involved in bacterial pathogenesis and so on. They also play important

roles in biosynthetic pathways.

ABC转运蛋白简介

2.2 Eukaryotic ABC proteins Although most eukaryotic ABC

transporters are effluxers, some are not directly involved in transporting

substrates. Human ABC transporters are involved in several diseases

that arise from polymorphisms in ABC genes and rarely due to complete

loss of function of single ABC proteins. More recently,

ABC-transporters have been shown to exist within the placenta.

ABC转运蛋白简介

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