2024年4月12日发(作者：)
利奈唑胺联合磷霉素对肠球菌的体外
药动学-药效学研究
摘要：
目的：研究利奈唑胺（LIN）与磷霉素（PM）联合对肠球菌的
体外药动学/药效学特性。
方法：采用微量平板洗涤技术，应用CASP（药物组合作用研
究）和min-inhibitory concentration（MIC）等实验方法，
研究了不同浓度下LIN和PM联合对肠球菌的体外药动学/药效
学，包括最小抑菌浓度（MIC）、最小杀菌浓度（MBC）、合作
指数（CI）和检测时间（T）等指标。
结果：与单用LIN或PM相比，在各浓度下，LIN联合PM的
MIC和MBC值均降低。联合组的CI值也较单用组（CI=1）有
所提高，并具有示踪效应。此外，联合组所需时间（T）同样
显著减少。
结论：LIN联合PM对肠球菌的体外药效明显优于单用LIN或
PM，具有合作增强效果和时间缩短的双重优势，足以作为治疗
此细菌感染的一种常见方法。
关键词：利奈唑胺、磷霉素、肠球菌、药动学、药效学
Abstract:
Purpose: To study the in vitro pharmacokinetics and
pharmacodynamics of combined use of linezolid (LIN)
and phosphomycin (PM) against enterococcus.
Methods: Micro-plate washing technique, CASP (drug
combination action research) and min-inhibitory
concentration (MIC) were used to study the in vitro
pharmacokinetics and pharmacodynamics of different
concentrations of LIN and PM in combination against
enterococcus. The indicators included minimum
inhibitory concentration (MIC), minimum bactericidal
concentration (MBC), Cooperating index (CI), and
detection time (T).
Results: Compared with single use of LIN or PM, the
MIC and MBC values of LIN in combination with PM
decreased at various concentrations. The CI value of
the combination group was also higher than that of the
single use group (CI=1), and had a tracer effect. In
addition, the time required for the combination group
also decreased significantly.
Conclusion: The in vitro pharmacological effect of LIN
in combination with PM against enterococcus was
significantly better than that of single use of LIN or
PM, with the dual advantages of enhanced cooperation
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