2024年4月27日发(作者：函数计算器在线计算)

冠状病毒Coronavirusl-2021 Coronavirus

1、

DiseaseWatchAPRIMEEXAMPLEFORANHIVVACCINEHIVvaccineshavehadlimitedsucc

essinhumantrials,andprotectiveCD8+

previousvaccinetrialforsimianimmunodeficiencyvirus(SIV),SIVprotein-ex

pressingrhesuscytomegalovirusstrain 68-1vectorsprovedsuccessfulforth

egenerationandmaintenanceofbroadCD8+udyn

2、

owrevealsthatthesevectorselicitSIV-specificCD8+Tcellsthatrecognizehig

hlydiverseandpromiscuousSIVepitopes,asopposedtothesmallrangeofepitope

sthataretargetedduringnaturalSIVinfectionandelicitanarrowCD8+T cellr

picalvaccineresp

onseoccursbecausethevectorscarrythegeneRh189,whichsuppressest

3、

hetargetingofnaturalepitopes,andalsolackRh157.4,Rh157.5andRh157.6,whi

challowsprimingofCD8+TcellsbybothmajorhistocompatibilitycomplexclassI

andclass pondinggenesexistin

humancytomegalovirus,

ONAVIRUSCONTROVERSYThenovelcoronavirus,MiddleEastrespiratorys

4、

yndromecoronavirus(MERS-CoV),continuestocausenewinfections,withtherep

a

第 3 页

lreservoirofinfectionisunknown,buthuman-to-humantransmissionissuspect

toftheongoingtransmission,WHOchiefMargaretChanhasurge

dthataglobalresponseisneededtocopewiththisthreat.“Thenovelco

5、

ronavirusisnotaproblemthatanysingleaffectedcountrycankeeptoitselforma

nageallbyitself,”shesaidduringtheclosingremarksoftheWorldHealthAssem

ametime,apatentclaimispendingforMERS-CoV-relatedapp

licationsbytheErasmusUniversityMedicalCentre(Rotterdam,theNetherlands

),whereMERS-CoVwasfirstisolated,leadingtheSaudiArabianHealthM

6、

etChansaidthatshe“wi

lllookatthelegalimplications”.WHO/BBCNewsANARMSRACEWITHH7N9Thefirstc

asesofdrug-resistantH7N9influenzavirusinfectionwererecentlyreportedin

ahospitalinShanghai,eswereobtainedfromthreepatientswhofai

ledtocleartheinfectionafterantiviraltreatment,andgenetictestin

7、

grevealedthatthevirusescarriedaneuraminidasemutationthatistypicallyas

raldrugsarecurrentlytheonlyoptiontot

reatH7N9influenzainfections;however,thefirstcandidatevaccineswererece

inantvirusescontainingsyntheticH7N9haemagg

lutininandneuraminidasegeneshavebeendevelopedandarenowavaila

8、

bleforvaccinemanufacturers,andthedevelopmentofalive-attenuatedvaccine

/BBCNewsORIGINALRESEARCHPAPERHansen,

galovirusvectorsviolateCD8+e34

0,6135(2021)RESEARCHHIGHLIGHTSNATUREREVIEWS|MICROBIOLOGYVOLUME11|JULY

2021©htsreserved

第 4 页