2024年3月14日发(作者：诺基亚5630xm评测)
Zero-Length Cross-linkers
The smallest available reagent systems for bioconjugation are the
so-called zerolength
有效 试剂 生物偶联 所
谓的 零长度
cross-linkers. These compounds mediate the conjugation of two molecules by
交联剂 化合物 调解 结合 2mol
forming a bond containing no additional atoms. Thus, one atom of a molecule
is
形成 键 包含 额外的 原子 分
子
covalently attached to an atom of a second molecule with no intervening
linker or
共价结合 干预链接器
spacer. In many conjugation schemes, the final complex is bound together by
virtue of
间隔 方案 合成 绑定在一起
凭借
chemical components that add foreign structures to the substances being
cross-linked.
成分 结构体 成分
In some applications, the presence of these intervening linkers may be
detrimental to
应用 存在 介入的 连接器 有害
的
the intended use. For instance, in the preparation of hapten-carrier conjugates
the
预期用途 例如 制备了 半抗体 载体 轭化物
complex is formed with the intention of generating an immune response to
the attached hapten.
复杂 形成 生成的意图 免疫反应
附加的
Occasionally, a portion of the antibodies produced by this response
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